You have 20,000 to 25,000 genes telling your body how to function on a molecular level. APOE is one of those genes.

The full name is Apolipoprotein E genotype. It tells your body how to make the Apolipoprotein E protein or APOE. The protein version helps form lipoproteins like VLDL that travel through your bloodstream to maintain a healthy amount of cholesterol and triglycerides in circulation. Genetic variations of the APOE gene can put you at higher risk for late-onset Alzheimer’s disease, Lewy body dementia, and heart diseases like atherosclerosis.

Test to know your disease risk, and then do something to help prevent those health issues.

There are 3 common alleles or versions of APOE: E2, E3 and E4. They come in pairs, because you received one allele from your mom, and the other from your dad. For example, you might have APOE E3/E3 along with most of the world. Or you could have APOE E4/E4 and have a much greater risk for brain and heart disease. Variations of the APOE gene are inherited from your parents. Each of the (6) variant pairs comes with a different level of disease risk. What APOE variation do you have? Find out with just a few clicks and a pain-free mouth swab.

Each kit contains 1 set of instructions, 1 small envelope, 1 plastic tube with a swab inside, 1 biohazard bag, 1 name label sticker, and 1 FedEx Return Pak.

Once you’ve sent your sample back to the lab, we’ll offer your results within 3 days. Your results will tell you if you have a variation of the APOE gene. The most common alleles of this gene are E2, E3 and E4. You'll have one copy from your mom and another copy from your dad. Results will appear as one of the following (6) pairs: E3/E3, E2/E2, E2/E3, E4/E4, E3/E4, or E2/E4.

You should firmly swab the inside of your right cheek for 15 seconds in a circular motion. Switch sides and firmly rub the inside of your left cheek for 15 seconds. After collection, place the swab back into the collection tube and push to secure the white cap until it makes a "click" sound. Don’t forget to ship your sample the same day you collect it. To ensure stability of the sample, we recommend you collect and ship samples Monday through Thursday only.

APOE E2/E2 means you have an average risk of developing late-onset Alzheimer’s in your lifetime, and it's associated with lower total cholesterol, and lower LDL cholesterol.

APOE E2/E3 means you have lesser risk of developing late-onset Alzheimer’s in your lifetime, and it's associated with lower total cholesterol, and lower LDL cholesterol.

APOE E2/E4 means you have a moderate risk of developing late-onset Alzheimer’s or dementia with Lewy bodies in your lifetime, and it's associated with higher total cholesterol, and higher LDL cholesterol.

APOE E3/E3 means you have lesser risk of developing late-onset Alzheimer’s in your lifetime, and it's associated with lower total cholesterol, and lower LDL cholesterol.

APOE E3/E4 means you have a moderate risk of developing late-onset Alzheimer’s or dementia with Lewy bodies in your lifetime, and it's associated with higher total cholesterol, and higher LDL cholesterol.

APOE E4/E4 means you have a high risk of developing late-onset Alzheimer’s and elevated risk for dementia with Lewy bodies in your lifetime, and it's associated with higher total cholesterol, and higher LDL cholesterol.

(1) Consistently exercise. (2) Significantly reduce your blood pressure if it's too high. (3) Ask your doctor about starting cognitive training sessions. (4) Test for deficiencies in folate (B9), vitamin A, vitamin B12, vitamin C and vitamin E and ask your doctor about supplementation. (5) Control your blood sugar if you have insulin resistance, prediabetes or diabetes. (6) If you're obese, aim to lose enough weight to get your BMI below 30. If you're overweight, aim for a BMI below or close to 25. (7) Test your thyroid to make sure it's functioning properly since thyroid issues could contribute to cognitive decline. (8) Test your hs-CRP levels to assess your level of inflammation, take action to get healthier, and then retest your hs-CRP levels to make sure your inflammation is going down over time. (9) Consider a heavy metal toxicity test if you think you’ve been exposed to aluminum, mercury and cadmium in your lifetime; these metals are strongly correlated with Alzheimer's.

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